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Journal of Lipid Research, Vol. 50, 1901-1909, September 2009
Copyright © 2009 by American Society for Biochemistry and Molecular Biology

Patient-Oriented and Epidemiological Research

Measures of postprandial lipoproteins are not associated with coronary artery disease in patients with type 2 diabetes mellitus¹

Gissette Reyes-Soffer^*, Steve Holleran, Wahida Karmally, Colleen I. Ngai^*, Niem-Tzu Chen^*, Margarita Torres^*, Rajasekhar Ramakrishnan, William S. Blaner^*, Lars Berglund^*, Henry N. Ginsberg^2,* and Catherine Tuck^1,*

^* Departments of Medicine, Columbia University Medical Center, New York, NY 10032
Pediatrics, Columbia University Medical Center, New York, NY 10032
Irving Institute for Clinical and Translational Research, Columbia University Medical Center, New York, NY 10032

² To whom correspondence should be addressed. e-mail: hng1{at}columbia.edu

Individuals with type 2 diabetes mellitus (DM) characteristically have elevated fasting and postprandial (PP) plasma triglycerides (TG). Previous case-control studies indicated that PPTG levels predict the presence of coronary artery disease (CAD) in people without DM; however, the data for patients with DM are conflicting. Therefore, we conducted a case-control study in DM individuals, 84 with (+) and 80 without (–) CAD. Our hypothesis was that DM individuals with or without CAD would have similar PPTG levels, but CAD+ individuals would have more small d<1.006 g/L lipoprotein particles. Several markers of PP lipid metabolism were measured over 10 h after a fat load. PP lipoprotein size and particle number were also determined. There was no significant difference in any measure of PP lipid metabolism between CAD+ and CAD–, except for apoB48, which was actually higher in CAD–. We followed 69 CAD– participants for a mean 8.7 years; 33 remained free of any cardiovascular event. There were no PP differences at baseline between these 33 who remained CAD– and either the 36 original CAD– who subsequently developed CAD or the original CAD+ group.PP measurements of TG-rich lipoproteins do not predict the presence of CAD in individuals with DM.

Supplementary key words triglycerides • apolipoprotein B48 • remnant lipoproteins

Abbreviations: apo, apolipoprotein; ASCVD, atherosclerotic cardiovascular disease; BMI, body mass index; C, cholesterol; IAUC, incremental area under the curve; CAD, coronary artery disease; DM, diabetes mellitus; IDL, intermediate density lipoprotein; MI, myocardial infarction; PP, postprandial; PPL, postprandial lipemia; RP, retinyl palmitate; TG, triglyceride

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