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J. Lipid Res.
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Originally published In Press as doi:10.1194/jlr.R800052-JLR200 on October 21, 2008

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Journal of Lipid Research, Vol. 50, S109-S114, April 2009
Copyright © 2009 by American Society for Biochemistry and Molecular Biology

Metabolism

Lipin proteins and metabolic homeostasis

Karen Reue1 and Jennifer R. Dwyer

Departments of Human Genetics and Medicine, and Molecular Biology Institute, University of California, Los Angeles, CA 90095

The authors gratefully acknowledge support from the National Institutes of Health HL-28481 and HL-90553 (K.R.) and the Ruth L. Kirschstein National Research Service Award GM07185 (J.R.D.).

Published, JLR Papers in Press, October 21, 2008.

1 To whom correspondence should be addressed. e-mail: reuek{at}ucla.edu


ABSTRACT

The lipin protein family, consisting of three members, was first identified early this century. In the last few years, the lipin proteins have been shown to have important roles in glycerolipid biosynthesis and gene regulation, and mutations in the corresponding genes cause lipodystrophy, myoglobinuria, and inflammatory disorders. Here, we review some of the progress toward elucidating the molecular and physiological functions of the lipin proteins.

Supplementary key words lipodystrophy • obesity • triglyceride • phosphatidate phosphatase • insulin resistance

Abbreviations: fld, fatty liver dystrophy; PAP, phosphatidate phosphatase; PPAR{alpha}, peroxisome proliferator-activated receptor {alpha}


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