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Journal of Lipid Research, Vol. 50, S195-S200, April 2009
Copyright © 2009 by American Society for Biochemistry and Molecular Biology

Lipoprotein Metabolism

The metabolism and anti-atherogenic properties of HDL

Kerry-Anne Rye^1,*,,, Christina A. Bursill^*, Gilles Lambert^*,**, Fatiha Tabet^* and Philip J. Barter^*,

^* Lipid Research Group, The Heart Research Institute, Sydney, NSW, Australia
Faculty of Medicine, University of Sydney, NSW, Australia
Department of Medicine, University of Melbourne, Victoria, Australia
^** Université de Nantes, Faculté de Médecine, Nantes, France

This work was funded by the NHMRC Grant Numbers 222722 and 482800. CAB is supported by a NHF Career Development Award and the Philip Bushell Foundation.

Published, JLR Papers in Press, November 24, 2008.

¹ To whom correspondence should be addressed. e-mail: ryek{at}hri.org.au

ABSTRACT

Population studies have shown that plasma HDL levels correlate inversely with cardiovascular disease risk. In recent years there has been intense interest in developing strategies for exploiting these cardioprotective properties by increasing HDL levels. While this approach has considerable merit, it is important to recognize that HDL are structurally and functionally diverse and consist of numerous, highly dynamic subpopulations of particles that do not all inhibit atherosclerosis to the same extent. For this reason it is essential to assess HDL subpopulation distribution and functionality when considering therapeutic interventions that raise HDL levels. This review documents what is known about the relationship between the metabolism and function of HDL subpopulations and how this affects their cardioprotective properties.

Supplementary key words HDL remodelling • HDL subpopulations • HDL function

Abbreviations: ABCA1, ATP binding cassette transporter A1; ABCG1, ATP binding cassette transporter G1; CETP, cholesteryl ester transfer protein; EL, endothelial lipase; HL, hepatic lipase; PLTP, phospholipid transfer protein; rHDL, reconstituted HDL; SR-B1, scavenger receptor-B1

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