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J. Lipid Res.
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Originally published In Press as doi:10.1194/jlr.R800055-JLR200 on December 9, 2008

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Journal of Lipid Research, Vol. 50, S225-S230, April 2009
Copyright © 2009 by American Society for Biochemistry and Molecular Biology

Signaling

Lipid phosphate phosphatases and signaling

David N. Brindley1 and Carlos Pilquil

Signal Transduction Research Group, Department of Biochemistry, University of Alberta, Edmonton, Alberta, T6G 2S2, Canada

The work was supported by the Canadian Institutes of Health Research.

Published, JLR Papers in Press, December 9, 2008.

1 To whom correspondence should be addressed. e-mail: david.brindley{at}ualberta.ca


ABSTRACT

Lipid phosphate phosphatases (LPPs) regulate cell signaling by modifying the concentrations of lipid phosphates versus their dephosphorylated products. The ecto-activity regulates the availability of extracellular lysophosphatidate (LPA) and sphingosine 1-phosphate (S1P) and thereby signaling by their respective receptors. LPP products (monoacylglycerol or sphingosine) are taken up by cells and rephosphorylated to produce LPA and S1P, respectively, which activate intracellular signaling cascades. The proposed integrin binding domain on the external surface of LPP3 modifies cell/cell interactions. Expression of LPPs on internal membranes controls signaling depending on the access of lipid phosphates to their active sites. Different LPPs perform distinct functions, probably based on integrin binding, their locations, and their abilities to metabolize different lipid phosphates in vivo.

Supplementary key words autotaxin • ceramide 1-phosphate • diacylglycerol • lysophosphatidate • phosphatidate • sphingosine 1-phosphate

Abbreviations: 2-AG, 2-arachidonoylglycerol; ATX, autotaxin; C1P, ceramide 1-phosphate; DAG, diacylglycerol; LPA, lysophosphatidate; LPC, lysophosphatidylcholine; LPP, lipid phosphate phosphatase; MAG, monoacylglycerol; PA, phosphatidate; PLA, phospholipase A; PLD, phospholipase D; S1P, sphingosine 1-phosphate


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JLR 50th Anniversary Collections
Anniversary Collection::Signaling

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