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J. Lipid Res.
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Originally published In Press as doi:10.1194/jlr.R800072-JLR200 on November 11, 2008

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Journal of Lipid Research, Vol. 50, S249-S254, April 2009
Copyright © 2009 by American Society for Biochemistry and Molecular Biology

Signaling

Phosphoinositide phosphatases and disease

Philip W. Majerus1,* and John D. York1,{dagger}

* Division of Hematology, Washington University School of Medicine, Box 8125, St. Louis, MO 63110
{dagger} Department of Pharmacology and Cancer Biology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710

This work is supported by funds from the Howard Hughes Medical Institute (J.D.Y.), and from the National Institutes of Health HL-55672 (J.D.Y.) and HL-016634 (P.W.M.)

Published, JLR Papers in Press, November 11, 2008.

1 To whom correspondence should be addressed. e-mail: phil{at}dom.wustl.edu (P.W.M.); yorkj{at}duke.edu (J.D.Y.)


ABSTRACT

The field of inositol signaling has expanded greatly in recent years. Given the many reviews on phosphoinositide kinases, we have chosen to restrict our discussion to inositol lipid hydrolysis focused on the phosphatases and a brief mention of the lipase isoforms. We also discuss recent discoveries that link mutations in phosphoinositide phosphatases to disease.

Supplementary key words membrane trafficking • lipid code • kinase • myotubularin • Lowe syndrome • Charcot-Marie-Tooth disease • Jobert syndrome

Abbreviations: DAG, diacylglycerol; ER, endoplasmic reticulum; ESCRT, endosomal sorting complex required for transport; GFP, green fluorescent protein; ING2, inhibitor of growth protein-2; MTM, myotubularin; MTMR, myotubularin-related protein; 3PAP, 3-ptase adaptor protein; PHD, plant homeodomain; PIP, phosphoinositide; PLC, phospholipase C; 5-ptase, 5-phosphatase


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JLR 50th Anniversary Collections
Anniversary Collection::Signaling



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