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J. Lipid Res.
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Originally published In Press as doi:10.1194/jlr.R800047-JLR200 on December 8, 2008

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Journal of Lipid Research, Vol. 50, S293-S298, April 2009
Copyright © 2009 by American Society for Biochemistry and Molecular Biology

Receptors

Lysophospholipid receptors in vertebrate development, physiology, and pathology

Athanasia Skoura and Timothy Hla1

Center for Vascular Biology, University of Connecticut Health Center, Farmington, CT 06030

Published, JLR Papers in Press, December 8, 2008.

1 To whom correspondence should be addressed. e-mail: hla{at}nso2.uchc.edu


ABSTRACT

Lysophospholipid (LP) research has experienced a period of renaissance with the discovery of the lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) receptors in the late 1990s. Vertebrate LP receptors regulate embryogenesis, vascular development, neurogenesis, uterine development, oocyte survival, immune cell trafficking and inflammatory reactions. LP signaling is important in cancer, autoimmunity and inflammatory diseases. Research on LP biology has contributed to the development of a first-generation S1P receptor modulator that has entered phase III clinical trials for the treatment of multiple sclerosis. Further basic research on LP signaling is anticipated to lead to novel therapeutic tools to combat various human diseases.

Supplementary key words sphingosine 1-phosphate • lysophosphatidic acid • G protein-coupled receptor

Abbreviations: LP, lysophospholipid; LPA, lysophosphatidic acid; LPP, lipid phosphate phosphatase; S1P, sphingosine 1-phosphate; SphK, sphingosine kinase


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JLR 50th Anniversary Collections
Anniversary Collection::Receptors

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