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J. Lipid Res.
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Originally published In Press as doi:10.1194/jlr.R800041-JLR200 on October 30, 2008

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Journal of Lipid Research, Vol. 50, S305-S310, April 2009
Copyright © 2009 by American Society for Biochemistry and Molecular Biology

Membranes and Lipid Domains

Molecular genetic approaches to defining lipid function

William Dowhan1

Department of Biochemistry and Molecular Biology and the Center for Membrane Biology, University of Texas Medical School-Houston, Houston, TX 77030

The work of the author was supported in part by National Istitutes of Health grant GM20478 and the John S. Dunn, Sr. Research Foundation.

Published, JLR Papers in Press, October 30, 2008.

1 To whom correspondence should be addressed. e-mail: William.Dowhan{at}uth.tmc.edu


ABSTRACT

Lipids fulfill multiple and diverse functions in cells. Establishing the molecular basis for these functions has been challenging due to the lack of catalytic activity of lipids and the pleiotropic effects of mutations that affect lipid composition. By combining molecular genetic manipulation of membrane lipid composition with biochemical characterization of the resulting phenotypes, the molecular details of novel lipid functions have been established. This review summarizes the results of such a combined approach to defining lipid function in bacteria.

Supplementary key words phosphatidylethanolamine • cardiolipin • phosphatidylglycerol • lactose permease • membrane domains • topogenesis • lipid genetics

Abbreviations: CL, cardiolipin; LacY, lactose permease; MGlcDAG, monoglucosyl diacylglycerol; MinCDE, three component system responsible for positioning Z-ring at septum; NAO, 10-N-nonyl acridine orange; PG, phosphatidylglycerol; PE, phosphatidylethanolamine; PS, phosphatidylserine; TM, transmembrane domain


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Related Webpages:

JLR 50th Anniversary Collections
Anniversary Collection::Membranes and Lipid Domains



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