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J. Lipid Res.
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Originally published In Press as doi:10.1194/jlr.R800049-JLR200 on October 23, 2008

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Journal of Lipid Research, Vol. 50, S311-S316, April 2009
Copyright © 2009 by American Society for Biochemistry and Molecular Biology

Membranes and Lipid Domains

Membrane phospholipid synthesis and endoplasmic reticulum function

Paolo Fagone and Suzanne Jackowski1

Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105-3678

This work was supported by National Institutes of Health Grant GM-45737, by Cancer Center Support Grant CA21765, and by the American Lebanese Syrian Associated Charities.

Published, JLR Papers in Press, October 23, 2008.

1 To whom correspondence should be addressed. e-mail: suzanne.jackowski{at}stjude.org


ABSTRACT

This review presents an overview of mammalian phospholipid synthesis and the cellular locations of the biochemical activities that produce membrane lipid molecular species. The generalized endoplasmic reticulum compartment is a central site for membrane lipid biogenesis, and examples of the emerging relationships between alterations in lipid composition, regulation of membrane lipid biogenesis, and cellular secretory function are discussed.

Supplementary key words phospholipids • sphingolipids • plasmalogens • unfolded protein response

Abbreviations: CCT, cytidylyltransferase; Cer, ceramide; CL, cardiolipin; DG, diacylglycerol; DGP, diacylglycerol phosphate; ER, endoplasmic reticulum; ERGIC, ER-Golgi intermediate compartment; MCS, membrane contact site; UPR, unfolded protein response; XBP-1, X-box binding protein 1


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Related Webpages:

JLR 50th Anniversary Collections
Anniversary Collection::Membranes and Lipid Domains



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Copyright © 2009 by the American Society for Biochemistry and Molecular Biology.
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