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Originally published In Press as doi:10.1194/jlr.R800040-JLR200 on October 27, 2008

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Journal of Lipid Research, Vol. 50, S323-S328, April 2009
Copyright © 2009 by American Society for Biochemistry and Molecular Biology

Membranes and Lipid Domains

The challenge of lipid rafts

Linda J. Pike1

Washington University School of Medicine Department of Biochemistry and Molecular Biophysics, St. Louis, MO 63110

This work was supported by National Institutes of Health grants RO1 GM064491 and R01 GM082824 to LJP.

Published, JLR Papers in Press, October 27, 2008.

1 To whom correspondence should be addressed. e-mail: pike{at}biochem.wustl.edu


ABSTRACT

The Singer-Nicholson model of membranes postulated a uniform lipid bilayer randomly studded with floating proteins. However, it became clear almost immediately that membranes were not uniform and that clusters of lipids in a more ordered state existed within the generally disorder lipid milieu of the membrane. These clusters of ordered lipids are now referred to as lipid rafts. This review summarizes current thinking on the nature of lipid rafts focusing on the role of proteomics and lipidomics in understanding the structure of these domains. It also outlines the contribution of single-molecule methods in defining the forces that drive the formation and dynamics of these membrane domains.

Supplementary key words cholesterol • lipid domains • proteomics • lipidomics • line tension


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JLR 50th Anniversary Collections
Anniversary Collection::Membranes and Lipid Domains

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