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J. Lipid Res.
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Originally published In Press as doi:10.1194/jlr.R800059-JLR200 on November 23, 2008

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Journal of Lipid Research, Vol. 50, S335-S339, April 2009
Copyright © 2009 by American Society for Biochemistry and Molecular Biology

Atherogenesis

Diabetes and atherosclerosis: is there a role for hyperglycemia?

Alan Chait1,* and Karin E. Bornfeldt{dagger}

* Departments of Medicine and Diabetes and Obesity Center of Excellence, University of Washington School of Medicine, Seattle, WA 98109
{dagger} Department of Pathology and Diabetes and Obesity Center of Excellence, University of Washington School of Medicine, Seattle, WA 98109

Research in the authors' laboratories is funded by National Institutes of Health grants HL30086, HL92969, and HL18645 to A.C.; and HL62887, HL92969, and 5-2008-257 from the Juvenile Diabetes Research Foundation to K.E.B.

Published, JLR Papers in Press, November 23, 2008.

1 To whom correspondence should be addressed. e-mail: achait{at}u.washington.edu


ABSTRACT

Atherosclerosis is accelerated in both type 1 and type 2 diabetes. The hallmark of diabetes is the presence of hyperglycemia. In this article, we review the role of glucose in the pathogenesis of atherosclerosis. Evidence obtained from epidemiological, in vitro, and animal studies will be reviewed in an attempt to understand the complex relationship between hyperglycemia and cardiovascular risk that is emerging from clinical trials.

Supplementary key words glycemic control • lesion initiation • lesion progression • dyslipidemia • cardiovascular risk • epidemiology • animal studies


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Related Webpages:

JLR 50th Anniversary Collections
Anniversary Collection::Atherogenesis



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