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Originally published In Press as doi:10.1194/jlr.R800092-JLR200 on December 2, 2008

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Journal of Lipid Research, Vol. 50, S364-S369, April 2009
Copyright © 2009 by American Society for Biochemistry and Molecular Biology

Atherogenesis

The role of adaptive T cell immunity in atherosclerosis

Ziad Mallat1, Soraya Taleb, Hafid Ait-Oufella and Alain Tedgui

Paris Cardiovascular Research Center, INSERM and Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, 75015 Paris, France

Ziad Mallat is a recipient of a Contrat d'Interface from Assistance Publique-Hôpitaux de Paris.

Published, JLR Papers in Press, December 2, 2008.

1 To whom correspondence should be addressed. e-mail: ziad.mallat{at}inserm.fr


ABSTRACT

There is now solid evidence that T cell adaptive immunity is involved in atherogenesis. While initial studies have focused on the pathogenic arm of the immune response, more recent work clearly suggests an important role for several subsets of regulatory T cells in the protection against lesion development. Here, we review the current knowledge on the role of both pathogenic and regulatory adaptive T cell immunity in atherosclerosis, generated mainly from the study of mouse models of the disease.

Supplementary key words inflammation • lymphocytes • cytokines

Abbreviations: DC, dendritic cell; IL, interleukin; iTreg, induced Treg cell; oxLDL, oxidized LDL; TGF, transforming growth factor


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JLR 50th Anniversary Collections
Anniversary Collection::Atherogenesis

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