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Journal of Lipid Research, Vol. 50, S40-S45, April 2009
Copyright © 2009 by American Society for Biochemistry and Molecular Biology

Enzymology

5-Lipoxygenase: mechanisms of regulation¹

Olof Rådmark² and Bengt Samuelsson

Department Medical Biochemistry and Biophysics, Division of Physiological Chemistry II, Karolinska Institutet, S-17177 Stockholm, Sweden

¹ This paper is dedicated to Professor E. J. Corey in connection with his 80th birthday.

Studies in our laboratory were supported by the Swedish Research Council (03X-217), Karolinska Institutet, and the European Union (LSHM-CT-2004-005033).

Published, JLR Papers in Press, November 5, 2008.

² To whom correspondence should be addressed. e-mail: olof.radmark{at}ki.se

ABSTRACT

5-Lipoxygenase (5-LO) catalyzes two steps in biosynthesis of leukotrienes (LTs), a group of lipid mediators of inflammation derived from arachidonic acid (AA). LT antagonists are used in treatment of asthma; more recently a potential role also in atherosclerosis has raised considerable interest. Furthermore, possible effects of 5-LO metabolites in relation to tumorigenesis have emerged. Thus, an understanding of the biochemistry of this lipoxygenase has potential implications for treatment of various diseases.

Supplementary key words arachidonic acid • leukotriene • inflammation

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