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Originally published In Press as doi:10.1194/jlr.R800094-JLR200 on December 17, 2008

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Journal of Lipid Research, Vol. 50, S423-S428, April 2009
Copyright © 2009 by American Society for Biochemistry and Molecular Biology

Lipids in Health and Disease

Prostanoids in health and disease

Emer M. Smyth, Tilo Grosser, Miao Wang, Ying Yu and Garret A. FitzGerald1

Institute for Translational Medicine and Therapeutics, University of Pennsylvania, PA 19104

This work was supported by grants from the National Institutes of Health (HL-83799, HL-62250, HL-081012, HL-066233, and RR-023567), the American Heart Association (Jon Holden DeHaan Foundation 0730314N, 0430148N, and 0735397N), and the University of Pennsylvania's Institute for Translational Medicine and Therapeutics' Transdisciplinary Program in Translational Medicine and Therapeutics (UL1RR024134).

Published, JLR Papers in Press, December 17, 2008.

1 To whom correspondence should be addressed. e-mail: garret{at}exchange.upenn.edu


ABSTRACT

The prostanoids are a family of lipid mediators generated by the action of cyclooxygenase on a 20-carbon unsaturated fatty acid, arachidonic acid. Prostanoids are generated widely in response to diverse stimuli and, acting in a paracrine or autocrine manner, play important roles in normal physiology and disease. This review summarizes the current knowledge on prostanoid generation and the roles of individual mediators, their biosynthetic pathways, and their receptors in health and disease.

Supplementary key words prostaglandins • lipids • autacoids

Abbreviations: AA, arachidonic acid; AAA, abdominal aortic aneurysm; Ang, angiotensin; COX, cyclooxygenase; IP, I prostanoid; NSAID, nonsteroidal anti-inflammatory drug; PG, prostaglandin; TxA2, thromboxane A2


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Related Webpages:

JLR 50th Anniversary Collection
Anniversary Collection:: Lipids in Health and Disease

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