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J. Lipid Res.
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Originally published In Press as doi:10.1194/jlr.R800076-JLR200 on November 22, 2008

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Journal of Lipid Research, Vol. 50, S434-S439, April 2009
Copyright © 2009 by American Society for Biochemistry and Molecular Biology

Lipids in Health and Disease

LDL cholesteryl oleate as a predictor for atherosclerosis: evidence from human and animal studies on dietary fat

Chiara Degirolamo, Gregory S. Shelness and Lawrence L. Rudel1

Department of Pathology, Section on Lipid Sciences, Wake Forest University School of Medicine, Winston-Salem NC 27157

The work presented here was made possible with the support of the National Institutes of Health grants HL-24736, HL-49373, and AT-002782.

Published, JLR Papers in Press, November 22, 2008.

1 To whom correspondence should be addressed: e-mail: lrudel{at}wfubmc.edu


ABSTRACT

This review focuses on the relationships among dietary fat type, plasma and liver lipid, and lipoprotein metabolism and atherosclerosis. Dietary polyunsaturated fatty acids are beneficial for the prevention of coronary artery atherosclerosis. By contrast, dietary monounsaturated fatty acids appear to alter hepatic lipoprotein metabolism, promote cholesteryl oleate accumulation, and confer atherogenic properties to lipoproteins as shown in data from experimental animal studies. Polyunsaturated fat appears to provide atheroprotection, at least in part, because it limits the accumulation of cholesteryl oleate in favor of cholesteryl linoleate in plasma lipoproteins.

Supplementary key words cholesteryl ester • lipoprotein metabolism • polyunsaturated fat • monounsaturated fat


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Related Webpages:

JLR 50th Anniversary Collections
Anniversary Collection:: Lipids in Health and Disease



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