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J. Lipid Res.
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Originally published In Press as doi:10.1194/jlr.R800043-JLR200 on October 27, 2008

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Journal of Lipid Research, Vol. 50, S69-S73, April 2009
Copyright © 2009 by American Society for Biochemistry and Molecular Biology

Metabolism

Regulation of phospholipid synthesis in yeast

George M. Carman1 and Gil-Soo Han

Department of Food Science and Rutgers Center for Lipid Research, Rutgers University, New Brunswick, NJ 08901

This work was supported in part by the United States Public Health Service, National Institutes of Health Grants GM-28140 and GM-50679.

Published, JLR Papers in Press, October 27, 2008.

2 The PAH1-encoded PA phosphatase is a Mg2+-dependent enzyme that is involved in de novo lipid synthesis. It is distinct from the DPP1- and LPP1-encoded lipid phosphate phosphatase enzymes that dephosphorylate PA and a host of lipid phosphate molecules by a catalytic mechanism that does not require Mg2+ (5). The DPP1- and LPP1-encoded enzymes play specific roles in controlling lipid phosphate metabolism confined to the vacuole and Golgi membranes, respectively (5).

1 To whom correspondence should be addressed. e-mail: carman{at}aesop.rutgers.edu


ABSTRACT

Phospholipid synthesis in the yeast Saccharomyces cerevisiae is a complex process that involves regulation by both genetic and biochemical mechanisms. The activity levels of phospholipid synthesis enzymes are controlled by gene expression (e.g., transcription) and by factors (lipids, water-soluble phospholipid precursors and products, and covalent modification of phosphorylation) that modulate catalysis. Phosphatidic acid, whose levels are controlled by the biochemical regulation of key phospholipid synthesis enzymes, plays a central role in the regulation of phospholipid synthesis gene expression.

Supplementary key words phospholipid synthesis • gene regulation • enzyme regulation • phosphatidic acid • yeast

Abbreviations: CDP-DAG, CDP-diacylglycerol; DAG, diacylglycerol; ER, endoplasmic reticulum; PA, phosphatidate; PC, phosphatidylcholine; PE, phosphatidylethanolamine; PI, phosphatidylinositol; PS, phosphatidylserine; TAG, triacylglycerol; UASINO, upstream activating sequence inositol-responsive element; UASZRE, upstream activating sequence zinc-responsive element


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JLR 50th Anniversary Collections
Anniversary Collection:: Metabolism

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K. Gulshan, P. Shahi, and W. S. Moye-Rowley
Compartment-specific Synthesis of Phosphatidylethanolamine Is Required for Normal Heavy Metal Resistance
Mol. Biol. Cell, February 1, 2010; 21(3): 443 - 455.
[Abstract] [Full Text] [PDF]


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