Journal of Lipid Research, Vol. 6, 135-139, January 1965
Copyright © 1965 by Lipid Research, Inc.
The 2-hydroxy fatty acids in white matter of infant and adult brains
L. F. Eng , B. Gerstl , R. B. Hayman , Y. L. Lee , R. W. Tietsort , and J. K. Smith
Research Laboratory, Veterans Administration Hospital, Palo Alto, California, and Department of Pathology, Stanford University, Stanford, California
White matter from five adult and five infant brains was analyzed for total fatty acids, galactolipids, and 2-hydroxy fatty acids. The distribution of 2-hydroxy fatty acids was determined quantitatively for each sample by gas-liquid chromatography of their methyl esters without masking their hydroxyl groups.
The galactolipid values in a case of multiple sclerosis and in the temporal areas of two other cases were about 25% lower than that reported for normal brains by other authors, but the content and composition of the 2-hydroxy fatty acids did not correlate with galactolipid contents and were similar for all adult samples.
The total fatty acid, galactolipid, and 2-hydroxy fatty acid concentrations in the infant brains were small compared with those of adults. The composition of the 2-hydroxy fatty acids was also different.
Supplementary key words brain • white matter • human • infant • adult • fatty acids • galactolipids • 2-hydroxy fatty acids • gas-liquid chromatography • multiple sclerosis
Submitted on May 21, 1964
Accepted on September 17, 1964
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