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Journal of Lipid Research, Vol. 6, 51-62, January 1965
Copyright © 1965 by Lipid Research, Inc.

Fatty acid synthesis during early linoleic acid deficiency in the mouse

David W. Allmann and David M. Gibson

Department of Biochemistry, Indiana University School of Medicine, Indianapolis, Indiana

The capacity of liver to synthesize long-chain fatty acids is greatly enhanced during early linoleate deficiency in mice. The enzymes catalyzing the synthesis of fatty acids from acetate or malonyl CoA were measured directly in soluble fractions isolated from liver.

The period of dietary restriction of linoleate is also accompanied by a rapid fall in the relative linoleate content of the liver; by marked changes in the composition of the fatty acids in liver; and by an accumulation of liver triglyceride.

Supplementary key words liver • fatty acid biosynthesis • linoleic acid • linoleic acid deficiency • fatty acid synthetase • fatty acid composition • acetyl CoA carboxylase • fatty liver • mouse

Submitted on June 22, 1964
Accepted on August 17, 1964


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