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Journal of Lipid Research, Vol. 6, 63-74, January 1965
Copyright © 1965 by Lipid Research, Inc.

Fatty acid synthesis during fat-free refeeding of starved rats

David W. Allmann , Dorothy D. Hubbard , and David M. Gibson

Department of Biochemistry, Indiana University School of Medicine, Indianapolis, Indiana

Refeeding starved rats a fat-free diet over a 48 hr period brings about a marked elevation in the activity of the enzymes in liver cytoplasm which catalyze the synthesis of saturated fatty acids from acetyl CoA and malonyl CoA. Acetate incorporation into palmitoleic and oleic acid is also accelerated during this period. Enhanced capability for the synthesis of these fatty acids is reflected in the net accumulation of saturated and monounsaturated fatty acids, as well as the triglyceride fraction of the liver lipids. Coincident with these events the relative amount of linoleic acid among liver fatty acids rapidly falls. These changes are substantially the same as those observed in early linoleic acid deficiency.

Supplementary key words rat • liver • linoleic acid • fatty acid composition • fatty acid biosynthesis • acetyl CoA carboxylase • fatty acid synthetase • fatty liver • fat-free refeeding • glucose-6-phosphate dehydrogenase • adaptive enzyme formation

Submitted on June 22, 1964
Accepted on August 17, 1964

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