Journal of Lipid Research, Vol. 6, 75-79, January 1965
Copyright © 1965 by Lipid Research, Inc.
Effects of a nutritional deficiency of unsaturated fats on the distribution of fatty acids in rat liver mitochondrial phospholipids
Ralph M. Johnson and Takeru Ito
Institute of Nutrition and Food Technology, and the Department of Physiological Chemistry, The Ohio State University, Columbus, Ohio
The fatty acid composition of liver mitochondrial phospholipids from rats rendered deficient in essential unsaturated fatty acids has been determined, and compared with that of rats fed a diet containing corn oil. In addition to marked reductions in the amounts of linoleic and arachidonic acids esterified at the ßbeta;-position of ethanolamine-, inositol-, and choline glycerophosphatides, the deficiency resulted in extensive changes in the distribution of saturated acids at both the 
- and ßbeta;-positions. Palmitoleic and oleic acids were increased in amount in fat deficiency, and large amounts of docosatrienoic acids appeared in these three phospholipids. The fatty acids of the sphingomyelins were not altered as a result of essential fatty acid deficiency.
The data demonstrate that each phospholipid is unique in the way in which its fatty acid moieties change in response to feeding a fat deficient diet.
Supplementary key words phospholipids • liver mitochondria • rat • essential fatty acids • fat deficiency • ethanol-amine glycerophosphatide • choline glycerophosphatide • serine glycerophosphatide • inositol glycerophosphatide • fatty acid composition
Submitted on June 11, 1964
Accepted on August 5, 1964
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