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Journal of Lipid Research, Vol. 6, 80-83, January 1965
Copyright © 1965 by Lipid Research, Inc.

Effects of alkali-metal ions on phospholipid and triglyceride synthesis in rat liver slices

R. S. Leal

Instituto Bento da Rocha Cabral, Lisbon, Portugal

The influence of alkali-metal ions on the incorporation of labeled precursors into phospholipids and triglycerides was studied in rat liver slices. By use of acetate-1-C¹⁴ and palmitate-1-C¹⁴ as lipid precursors, a comparison was made of the pathway from acetate to phospholipid and the pathway from palmitate to phospholipid. While the rate of incorporation of palmitate-1-C¹⁴ into phospholipids and triglyceride fatty acids was virtually independent of the alkali-metal ion present in the medium, the rate of incorporation of acetate-1-C¹⁴ into the same compounds was strongly influenced by the alkali-metal ions, the highest incorporations being obtained with potassium and rubidium. Under the same conditions lithium appears to have an inhibitory effect. The effects of the alkali-metal ions on phospholipid and triglyceride synthesis in liver are located on the pathway between acetate and long-chain fatty acids.

Supplementary key words fatty acid biosynthesis • phospholipid biosynthesis • triglyceride biosynthesis • rat • liver slices • alkali-metal ions

Submitted on June 12, 1964
Accepted on August 8, 1964

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