Journal of Lipid Research, Vol. 6, 91-95, January 1965
Copyright © 1965 by Lipid Research, Inc.
Release of free fatty acids from adipose tissue obtained from newborn infants
Milan Novák , Václav Melichar , Petr Hahn , and Otakar Koldovsk
Institute for the Care of Mother and Child and Institute of Physiology, Czechoslovak Academy of Sciences, Prague, Czechoslovakia
The role played by mobilization of free fatty acids (FFA) from adipose tissue in producing the typically high serum FFA levels of human infants has been studied. FFA concentrations in the serum and subcutaneous adipose tissue from the gluteal region were determined during postnatal development. A maximum level was reached within 24 hr after birth, after which there was a gradual fall. In serum the FFA level at the end of 12 months was still higher than that in adults, while the FFA level in adipose tissue was lower at 3 months than in adults.
Incubation of small pieces of adipose tissue in Krebs-Ringer phosphate buffer containing 4% albumin led to release of FFA into the medium. This release could be suppressed by the addition of glucose (200 mg/100 ml) for tissue from all age groups except the youngest (0-15 hr after birth).
Supplementary key words free fatty acids • adipose tissue • infants • incubation • needle aspiration • metabolism
Submitted on February 24, 1964
Accepted on August 12, 1964
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