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Journal of Lipid Research, Vol. 6, 494-497, October 1965
Copyright © 1965 by Lipid Research, Inc.

Metabolism of arachidonic acid-1-¹⁴C in the rat

Robert H. Coots

The Procter & Gamble Company, Miami Valley Laboratories, Cincinnati, Ohio

The metabolism of arachidonic acid-1-¹⁴C has been studied in the rat. The acid was fed as a component of randomly rearranged soybean oil; its absorption was greater than 96%. The rate of catabolism of arachidonic acid was significantly lower than that previously seen for linoleic acid and other long-chain fatty acids. A marked tendency for arachidonic acid to be incorporated into phospholipids was observed. Arachidonic acid-containing phospholipids have been shown to have a slower turnover rate than linoleic and palmitic acid-containing phospholipids. It is proposed that this slower turnover rate is a reflection of the "essential" character of arachidonic acid and is a rational explanation for the slower catabolic rate of this acid.

Supplementary key words metabolism • arachidonic acid • rat absorption • catabolism

Submitted on February 2, 1965
Accepted on May 25, 1965

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