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Journal of Lipid Research, Vol. 6, 532-536, October 1965
Copyright © 1965 by Lipid Research, Inc.

Developing rat brain: changes in cholesterol, galactolipids, and the individual fatty acids of gangliosides and glycerophosphatides

Yasuo Kishimoto , W. Ewart Davies , and Norman S. Radin

Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan

Groups of brains from rats of various ages—7 to 275 days—were analyzed for their contents of galactolipids (cerebroside + cerebroside sulfate), cholesterol, and the individual fatty acids of the gangliosides and glycerophosphatides. Ganglioside stearate was found to accumulate at a steady pace during the first 20 days of life, then more slowly for at least 32 days more, then to decrease. Ganglioside arachidate, on the other hand, accumulated steadily throughout the period covered. The glycerophosphatide acids showed several inversions in the ratios between selected pairs of acids, the trend being toward increasing unsaturation and chain length. Higher contents of 22:6 and 20:4 acids than previously reported were found, presumably because of improved methods. The galactolipids and cholesterol were deposited at very similar rates after about 15 days, the molar ratio of the deposits (cholesterol/galactolipids) being about 2.2, the value found for purified myelin.

Supplementary key words gangliosides • glycerophosphatides • cerebrosides • sulfatides • cholesterol • fatty acids • rat • brain • age • docosahexaenoic acid • gas-liquid chromatography response • myelin

Submitted on April 21, 1965
Accepted on June 22, 1965

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