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Journal of Lipid Research, Vol. 6, 565-571, October 1965
Copyright © 1965 by Lipid Research, Inc.

Effect of chain length on rates of uptake of free fatty acids during in vitro incubations of rat adipose tissue

Jerome L. Knittle and Jules Hirsch

The Rockefeller University, New York, N. Y.

The incorporation into triglycerides of 1-¹⁴C-labeled saturated free fatty acids (FFA) of different chain lengths (C₂-C₁₆) was studied using incubation of rat epididymal fat pads in vitro. The results indicate that the rate at which adipose tissue incorporates FFA is dependent on chain length. With very short-chain acids a small amount is directly esterified into triglycerides, but the major portion is elongated and esterified. Analyses by means of Factice chromatography showed that acids with a chain length of 10 or longer were esterified without elongation.

Supplementary key words uptake • esterification • free fatty acids • adipose tissue • short-chain • long-chain • rat • isotope ratio method

Submitted on May 26, 1965
Accepted on July 2, 1965

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