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Journal of Lipid Research, Vol. 7, 116-121, January 1966
Copyright © 1966 by Lipid Research, Inc.

Effect of a new inhibitor of cholesterol biosynthesis (AY 9944) on serum and tissue sterols in the rat

L. Horlick

Department of Medicine, University of Saskatchewan, University Hospital, Saskatoon, Saskatchewan, Canada

AY 9944 is a novel inhibitor of cholesterol biosynthesis which appears to act on the ⁷-reductase enzyme, interfering with the conversion of 7-dehydrocholesterol to cholesterol. In all tissues studied, with the exception of the lens, there was a reduction in cholesterol and a marked accumulation of 7-dehydrocholesterol. Isotope studies showed a reduced uptake of acetate into cholesterol, and an increased uptake into 7-dehydrocholesterol, in various tissues in vivo and by skin samples in vitro. There was no apparent accumulation of lanosterol or of the methostenols in the rat skin.

Supplementary key words AY 9944 • inhibitor • biosynthesis • cholesterol • 7-dehydrocholesterol • accumulation • skin • aorta • liver • adrenal • kidney • lens • serum • rat • lanosterol • methostenol • ⁷-reductase

Submitted on May 5, 1965
Accepted on August 27, 1965

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