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Journal of Lipid Research, Vol. 7, 73-76, January 1966
Copyright © 1966 by Lipid Research, Inc.

Effect of sympathomimetic compounds with bgr-adrenergic effects on plasma free fatty acids in man

T. R. E. Pilkington , R. D. Lowe , R. Foster , B. F. Robinson , and A. Antonis

Medical Unit, St. George's Hospital Medical School, London, England

Nine sympathomimetic compounds were infused intravenously in man, and their effects on the level of plasma free fatty acids, pulse rate, and blood pressure were recorded. Each compound raised the level of plasma free fatty acids. Its activity in this respect could be correlated with its activity in producing bgr-adrenergic effects on the circulation; both effects were abolished by pretreatment with propranolol. It is concluded that sympathomimetic compounds that stimulate bgr-receptors will raise the plasma concentration of free fatty acids.

Supplementary key words sympathomimetic compounds • intravenous • plasma • free fatty acids • man • agr- and bgr-adrenergic • effects • blockade • phenoxybenzamine • propranolol

Submitted on July 19, 1965
Accepted on September 7, 1965


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