Journal of Lipid Research, Vol. 7, 215-220, March 1966
Copyright © 1966 by Lipid Research, Inc.

Lipid transfer between human serum high density lipoproteins and egg yolk lipoproteins in incubation mixtures

Alex V. Nichols and Elaine L. Coggiola

Donner Laboratory, Lawrence Radiation Laboratory, University of California, Berkeley, California

Ultracentrifugally isolated human serum high density lipoproteins of d 1.063-1.21 (HDL) were incubated with egg yolk lipoproteins of d < 1.006 for up to 24 hr at various concentrations. Transfer of HDL cholesterol esters to egg yolk lipoproteins occurred simultaneously with transfer of glycerides from egg yolk lipoproteins to HDL. These observations show that exchange of lipids can take place between lipoproteins in the absence of other serum proteins and enzymes. The mole ratios of HDL cholesterol esters to glycerides approached an integral value of 1 : 1 during the course of the incubation. These results suggest that lipid components form complexes within the HDL structure.

Supplementary key words lipoproteins • human plasma high density • egg yolk • incubation • lipid transfer • cholesterol esters • glycerides • mole ratios • complex formation

Submitted on September 2, 1965
Accepted on December 7, 1965

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?