Journal of Lipid Research, Vol. 7, 226-229, March 1966
Copyright © 1966 by Lipid Research, Inc.

Absorption, transport, and storage of retinyl-15-¹⁴C palmitate-9, 10-³H in the rat

C. W. Lawrence , F. D. Crain , F. J. Lotspeich , and R. F. Krause

Department of Biochemistry, West Virginia University Medical Center, Morgantown, West Virginia

Retinyl-15-¹⁴C palmitate-9,10-³H was fed to rats in order to study hydrolysis and reesterification of this ester during digestion, absorption, transportation, and storage. After administration there was a progressive increase in the ¹⁴C/³H ratio of the retinyl esters as they moved from intestinal contents to intestinal mucosa, lymph, and liver, which indicates that repeated hydrolysis and reesterification occur during the digestion and assimilation of this ester.

Supplementary key words retinyl ester • palmitate • hydrolysis • reesterification • absorption • lymph transport • liver • intestinal mucosa • microsomes • retinol • vitamin A • rat

Submitted on September 22, 1965
Accepted on December 3, 1965

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