Journal of Lipid Research, Vol. 7, 248-257, March 1966
Copyright © 1966 by Lipid Research, Inc.

Metabolism of hepatic and plasma triglycerides in rabbits given ethanol or ethionine

A. Bezman-Tarcher , P. J. Nestel , J. M. Felts , and R. J. Havel

Cardiovascular Research Institute and Department of Medicine, University of California School of Medicine, San Francisco, California

The formation and transport of hepatic triglyceride fatty acids (TGFA) were studied after intravenous administration of palmitate-1-¹⁴C or palmitate-9,10-³H in rabbits pretreated with ethanol or ethionine.

Administration of ethanol produced significant hypertriglyceridemia without consistent accumulation of hepatic fat. The isotopic studies suggest that plasma free fatty acids were the major precursors of TGFA in d < 1.006 lipoproteins and that fatty acids synthesized in the liver were not the source of the hypertriglyceridemia in the ethanol-treated animals.

Administration of ethionine resulted in an increased concentration of TGFA in the liver, a decreased level of TGFA in d < 1.006 lipoproteins and a very low specific activity in this plasma fraction. These findings suggest that the development of fatty liver after administration of ethionine is in part accompanied by impaired release of TGFA from the liver.

Supplementary key words long-term • short-term • ethanol • ethionine • rabbit • hepatic triglyceride fatty acid • hypertriglyceridemia • plasma free fatty acid • d < 1.006 lipoproteins • fatty liver

Submitted on August 4, 1965
Accepted on November 19, 1965

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?