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Journal of Lipid Research, Vol. 7, 270-276, March 1966
Copyright © 1966 by Lipid Research, Inc.

Decarboxylation of 2-keto fatty acids by brain

W. Ewart Davies , Amiya K. Hajra , Surendra S. Parmar , Norman S. Radin , and James F. Mead

Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan, and Laboratory of Nuclear Medicine and Radiation Biology, Department of Biophysics and Nuclear Medicine, School of Medicine, Center for the Health Sciences, University of California, Los Angeles, California

An enzyme system consisting of washed acetone powder of pig brain, adenosine triphosphate, nicotinamide adenine dinucleotide, magnesium, fumaric acid, and ascorbic acid was found to catalyze the oxidative decarboxylation of 2-ketostearic acid. The products were carbon dioxide and heptadecanoic acid. Washing the enzyme powder with ethylene-diaminetetraacetate and other chelating agents destroyed the activity. Further properties of the enzyme system are described. It is believed that this enzyme system accounts in part for the 1-carbon degradation route for brain fatty acids.

Supplementary key words 2-ketostearic acid • decarboxylation • brain • pig • ascorbic acid • fumaric acid • iron • fatty acid catabolism

Submitted on July 13, 1965
Accepted on December 8, 1965


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