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Journal of Lipid Research, Vol. 7, 357-367, May 1966
Copyright © 1966 by Lipid Research, Inc.

Evidence for centers in the central nervous system that regulate fat mobilization in dogs

Alan Goldfien , K. S. Gullixson , and G. Hargrove

Cardiovascular Research Institute and Departments of Obstetrics and Gynecology and Medicine, University of California School of Medicine, San Francisco, California

Infusions of 2-deoxyglucose (2-DG) into intact, adrenalectomized, and adrenalectomized-hypophysectomized dogs caused increases in plasma free fatty acid (FFA) levels which could be reversed by infusing hexamethonium, or prevented by epidural anesthesia or destruction of the thoracic spinal cord. Similar infusions of 2-DG were given to adrenalectomized dogs after transection of the spinal cord. Lesions between C 4 and T 7 prevented the increase in FFA while lesions at T 8 or C 2-3 did not.

These results indicate that inhibition of glucose metabolism by 2-DG causes an increase in plasma FFA by a pathway involving the sympathetic nervous system and that there are centers regulating this activity in the cervical portion of the spinal cord.

Supplementary key words central nervous system • fat mobilization • hypoglycemia • 2-deoxyglucose • spinal cord • hypophysectomy • adrenalectomy • sympathetic nervous system • growth hormone • sympathetic blockade • free fatty acids • glucose receptors • adipokinetic factors • chemoreceptors • adrenal medullary secretion

Submitted on September 24, 1965
Accepted on December 30, 1965


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