Journal of Lipid Research, Vol. 7, 524-530, July 1966
Copyright © 1966 by Lipid Research, Inc.

Characterization of trisubstituted cholanoic acids in human feces

P. Eneroth , B. Gordon , and J. Sjövall

Department of Chemistry, Karolinska Institutet, Stockholm, Sweden

The trisubstituted cholanoic acids in human feces have been studied by gas chromatography-mass spectrometry. The following bile acids have been identified: 3,7,12-trihydroxy-, 3,7,12-trihydroxy-, 3,7-dihydroxy-12-keto-5-cholanoic acids and 3,7,12-trihydroxy-5-cholanoic acid. The presence in human feces of 3,7,12-trihydroxy-, 3,7,12-trihydroxy-, and 3,12-dihydroxy-7-keto-5-cholanoic acids has been confirmed.

The composition of bile acids in human feces is summarized and possible metabolic interrelationships suggested.

Supplementary key words bile acids • trifluoroacetates • partial trimethylsilyl ethers • dimethylhydrazones • gas-liquid chromatography • mass spectrometry • identification • feces • man

Submitted on February 14, 1966
Accepted on April 5, 1966

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