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Journal of Lipid Research, Vol. 7, 684-691, September 1966
Laboratory of Metabolism, National Heart Institute and Laboratory of Neuropathology, National Institute of Neurological Diseases and Blindness, National Institutes of Health, Bethesda, Maryland
Feeding of phytol in large doses (2-5% by weight in the diet) led to accumulation of phytanic acid in the mouse, rat, rabbit, and chinchilla, the degree of accumulation depending upon the level of dietary intake. The relative concentration of phytanic acid, expressed as a percentage of the total fatty acids, was as high as 20-60% in liver and 30-40% in serum. Phytenic acid, which may be an intermediate in the conversion of phytol to phytanic acid, also accumulated. When phytol was withdrawn from the diet, tissue and serum concentrations of phytanic acid fell rapidly, which indicates the ability of the normal animal to metabolize phytanic acid readily. At high dosages in the diet, phytol inhibited growth and caused death within 1-4 weeks. In the mouse, dietary phytanic acid and dietary phytol fed in equivalent amounts were of comparable toxicity. Accumulation of tissue phytanic acid occurred more rapidly when phytanic acid was fed than when phytol was fed in equal amounts. In none of the animals fed either phytol or phytanic acid were there any signs of neurological defects. Histologic examination of rats fed phytol showed some fat accumulation, glycogen depletion, and karyokinesis in the liver. There were no pathologic changes in the retina or in the peripheral and central nervous system such as those described in Refsum's disease. Supplementary key words phytol • phytanic acid • phytenic acid • accumulation • rat • mouse • rabbit • chinchilla • branched-chain fatty acids • lipidoses • Refsum's disease
Submitted on March 21, 1966
Copyright © 1966 by Lipid Research, Inc.
Effects of dietary phytol and phytanic acid in animals
Accepted on June 20, 1966
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