Journal of Lipid Research, Vol. 8, 16-23, January 1967
Copyright © 1967 by Lipid Research, Inc.

Conversion of cholesterol injected into man to cholestanol via a 3-ketonic intermediate

R. S. Rosenfeld , Barnett Zumoff , and Leon Hellman

Institute for Steroid Research and the Division of Neoplastic Medicine, Montefiore Hospital and Medical Center, New York

Cholesterol-3-³H,4-¹⁴C was injected intravenously in man and its transformation to cholestanol was studied. From the ³H: ¹⁴C ratios in cholestanol isolated from blood, evidence for the participation of a ketonic intermediate in the conversion was obtained. In a second subject given cholestanol-3-³H,4-¹⁴C the ³H: ¹⁴C ratios in blood sterols remained unchanged for as long as 1 wk after the injection, which showed that cholestanol did not lose tritium by interconversion with cholestanone.

Supplementary key words cholesterol-cholestanol conversion • ketonic intermediate • man • cholesterol-3-³H,4-¹⁴C metabolism

Submitted on June 6, 1966
Accepted on August 26, 1966

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?