Journal of Lipid Research, Vol. 8, 24-29, January 1967
Copyright © 1967 by Lipid Research, Inc.

Hypolipidemic effects of orally administered dextran and cellulose anion exchangers in cockerels and dogs

Thomas M. Parkinson

Metabolic Diseases Research Laboratories, The Upjohn Company, Kalamazoo, Michigan

Various cellulose and dextran anion exchangers bind bile salts in vitro under conditions of pH and ionic strength resembling those in the lumen of the small intestine. Of these substances, diethylaminoethyl (DEAE) cellulose, guanidoethyl cellulose, and DEAE Sephadex reduced hypercholesterolemia when added to the diet of cholesterol-fed cockerels. In addition, DEAE Sephadex reduced serum sterols in normocholesterolemic cockerels and dogs, lowered serum phospholipids and triglycerides in cholesterol-fed hypercholesterolemic cockerels and in normocholesterolemic dogs, and increased fecal excretion of bile acids in hypercholesterolemic cockerels.

The data indicate that these insoluble cationic polymers exert their hypocholesterolemic effects by interrupting the enterohepatic circulation of bile acids.

Supplementary key words bile acids • degree of binding • anion exchangers • celluloses • DEAE Sephadex • hypocholesterolemic activity • serum lipids • fecal excretion • enterohepatic circulation • cockerel • dog

Submitted on June 6, 1966
Accepted on September 20, 1966

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				R.J. Courtenay Evans, A.N. Howard, and D.E. Hyams An Effective Treatment of Hypercholesterolaemia Using a Combination of Secholex(R) and Clofibrate Angiology, January 1, 1973; 24(1): 22 - 28. [PDF]