Journal of Lipid Research, Vol. 8, 138-141, March 1967
Copyright © 1967 by Lipid Research, Inc.

Serum lipoproteinemia in pregnant and lactating rats

Virgilio Bosch and German Camejo

Departamento de Ciencias Fisiológicas, Cátedra de Patología General y Fisiopatología, Universidad Central de Venezuela, Caracas, Venezuela

Serum lipoproteins of pregnant and puerperal rats were studied by preparative and analytical ultracentrifugation. The concentration for the fraction with density less than 1.019 was markedly elevated in rats during the 3rd wk of gestation and in lactating rats. This fraction showed similar triglyceride fatty acid composition and immunoelectrophoretic behavior whether it was derived from pregnant or nonpregnant rats, and when partially delipidized, the lipoproteins from both groups showed similar immunoelectrophoretic characteristics and sedimentation rates.

When lactation was interrupted during puerperium, serum lipoproteins returned to control levels; but in lactating rats, high levels of serum very low density lipoprotein persisted up to 3 wk post partum.

Supplementary key words rat • pregnant • lactating • serum • very low density lipoproteins • milk production • partial delipidation

Submitted on August 5, 1966
Accepted on December 2, 1966

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