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Journal of Lipid Research, Vol. 8, 142-145, March 1967
Copyright © 1967 by Lipid Research, Inc.

Use of esters of N-hydroxysuccinimide in the synthesis of N-acylamino acids

Y. Lapidot , S. Rappoport , and Y. Wolman

Department of Biological Chemistry and Department of Organic Chemistry, The Hebrew University of Jerusalem, Israel

Several crystalline N-hydroxysuccinimide esters of short- and long-chain fatty acids have been synthesized. These compounds react with free amino acids to form preferentially N-acylamino acids. The reaction of the N-hydroxysuccinimide esters with hydroxylamine and the behavior of the N-acylamino acids on thin-layer chromatography are described.

Supplementary key words lipoamino acids • N-acylamino acids • N-hydroxysuccinimide esters • thin-layer chromatography

Submitted on September 23, 1966
Accepted on December 1, 1966


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