Journal of Lipid Research, Vol. 8, 84-89, March 1967
Copyright © 1967 by Lipid Research, Inc.

Lipogenesis from amino acids in perfused isolated dog skin

Victor R. Wheatley , George Lipkin , and Tae Ha Woo

Department of Dermatology, New York University School of Medicine, New York 10016

Lipogenesis from amino acids has been studied in isolated perfused dog skin. Uniformly labeled alanine-¹⁴C, glycine-¹⁴C, isoleucine-¹⁴C, leucine-¹⁴C, phenylalanine-¹⁴C, and valine-¹⁴C are all incorporated into the cutaneous lipids, with significant incorporation into most of the isolated lipid fractions. Efficiency of lipogenesis has been expressed relative to the extent of incorporation of acetate under the same experimental conditions. This efficiency was highest for the three branched-chain amino acids.

The accuracy, uses, and limitations of the perfusion technique for the study of cutaneous lipogenesis have been evaluated.

Supplementary key words dog • skin • perfusion • lipogenesis • amino acids • branched-chain • fatty acids

Submitted on May 26, 1966
Accepted on November 1, 1966

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