J. Lipid Res. Neurobiology of Lipids (ISSN1683-5506)
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Journal of Lipid Research, Vol. 8, 90-96, March 1967
Copyright © 1967 by Lipid Research, Inc.

Metabolism of chylomicrons by the isolated rat liver

Joseph A. Ontko and D. B. Zilversmit

Department of Physiology and Biophysics, University of Tennessee Medical Units, Memphis

Isolated livers perfused with washed corn oil chylomicrons labeled in vivo with palmitic acid-1-14C removed a large proportion of the chylomicrons. Slices from these livers oxidized chylomicron fatty acid esters to both carbon dioxide and acetoacetate. The liver slices also generated free fatty acids from chylomicron lipids and converted chylomicron triglycerides to phospholipids. Similar activities were observed in rat liver slices prepared shortly after the intravenous administration of chylomicrons to intact rats.

The observed chylomicron uptake and lipid conversions were similar in livers from both fed and fasted rats. Fasting increased the oxidation of chylomicron fatty acid esters by livers labeled in vivo and by perfusion.

In livers removed from intact rats given labeled chylomicrons, the triglyceride-14C to phospholipid-14C ratio was high, a finding unexpected if the liver had acquired this 14C by removal of circulating fatty acids formed by extrahepatic lipolysis.

These results demonstrate the ability of the liver to remove and utilize chylomicrons directly and suggest that direct removal accounts for a significant portion of the chylomicron fatty acids utilized by the liver of intact rats.

Supplementary key words chylomicrons • rat • liver • perfusion • slices • fatty acid oxidation • ketogenesis • lipolysis

Submitted on July 16, 1966
Accepted on November 1, 1966


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