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Journal of Lipid Research, Vol. 8, 97-104, March 1967
Copyright © 1967 by Lipid Research, Inc.
Department of Internal Medicine, The University of Texas Southwestern Medical School, Dallas, Texas 75235
Rates of sterol synthesis were measured in 17 tissues of the rat, and the responsiveness of these rates to cholesterol feeding and to fasting was determined. The liver and gastrointestinal tract together account for 90% of synthetic activity of the whole body. After the rats had been fed cholesterol or fasted, liver synthesis was markedly decreased, whereas synthetic rates in all other organs tested were essentially unaffected (this conclusion applies to synthesis of cholesterol and of five other digitonin-precipitable tissue sterols). Consequently, the highest rate of cholesterogenesis in the cholesterolfed or fasted rat is found in the gastrointestinal tract.
Supplementary key words rat • cholesterol synthesis • liver • intestine • extrahepatic tissues • feedback control • intermediate sterols • fasting • cholesterol feeding
Submitted on August 12, 1966
Accepted on November 30, 1966
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