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Journal of Lipid Research, Vol. 8, 210-214, May 1967
Copyright © 1967 by Lipid Research, Inc.

Dietary fat and cholesterol and serum cholesterol in the gerbil

D. M. Hegsted and Anna Gallagher

Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115

Groups of gerbils were fed purified diets containing either 10 or 20% of safflower, olive, or coconut oil. Each diet was fed without cholesterol and with 0.1 and 0.2% of added cholesterol. The animals were bled after 2, 4, and 8 wk for the determination of the level of serum cholesterol. The major factors affecting the level of serum cholesterol were the kind of dietary oil, the amount of dietary cholesterol, and the length of time the diet was fed. The level of safflower oil had a statistically significant effect but the level of olive or coconut oil had no significant effect. Various other statistically significant interactions were observed which make simple interpretations of the data difficult.

The levels of serum cholesterol achieved in the gerbils fed the different oils with no or very low levels of dietary cholesterol were similar to those seen in men fed the same oils. Although the gerbil is apparently resistant to the development of atherosclerosis, it may be a useful model for studying the effect of dietary fats upon cholesterol metabolism.

Supplementary key words gerbil • serum cholesterol • dietary fat • cholesterol • hypercholesterolemia

Submitted on October 7, 1966
Accepted on January 18, 1967

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