Journal of Lipid Research, Vol. 8, 274-280, May 1967
Copyright © 1967 by Lipid Research, Inc.

Relationship of lipoprotein lipase activity to triglyceride uptake in adipose tissue

Arlene S. Garfinkel , Nome Baker , and Michael C. Schotz

Radioisotope Research, Veterans Administration, Los Angeles, California 90073, and Department of Biological Chemistry, University of California at Los Angeles School of Medicine, Los Angeles, California 90024

Fasted rats injected with actinomycin or fed glucose show increased lipoprotein lipase activity of epididymal adipose tissue. Data from the actinomycin-treated animals showed a direct correlation between the lipoprotein lipase activity and the uptake of lipoprotein triglyceride by the epididymal fat pad in vitro and in vivo. Data from the animals fed glucose confirmed these findings in vitro. These data strongly suggest that lipoprotein lipase plays a major role in triglyceride deposition in adipose tissue.

Supplementary key words lipoprotein lipase • triglyceride uptake • fat deposition • adipose tissue • actinomycin D • glucose feeding • very low density lipoprotein • rat

Submitted on October 7, 1966
Accepted on January 24, 1967

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