Journal of Lipid Research, Vol. 8, 308-311, July 1967
Copyright © 1967 by Lipid Research, Inc.

Occurrence of positional isomers of octadecenoic and hexadecenoic acids in human depot fat

Jürgen Jacob and Gernot Grimmer

Universität Hamburg, Hamburg, Germany

Positional isomers of hexadecenoic aud octadecenoic acids of human adipose tissue have been separated by gas-liquid chromatography and their amounts determined by oxidative cleavage (MnO₄ and IO₄). The following isomeric octadecenoic acids were present: 7-octadecenoic acid (0.4%), 8- (1.9%), 9- (73.0%), 10- (2.5%), 11- (19.0%) and 12- (3.2%). The hexadecenoic acids have also been shown to be a mixture of positional isomers, in which the cis-9-isomer predominates. 10-Hexadecenoic and 12-octadecenoic acids could conceivably be precursors of linoleic acid.

The following branched fatty acids have also been determined in human depot fat: 13-methyltetradecanoic, 12-methyltetradecanoic, 14-methylpentadecanoic, 14-methylhexadecanoic, and 16-methylheptadecanoic acid. They were present in percentages of 0.02-0.6% and their identification rests solely on comparison of their gas-liquid chromatographic retention times with those of synthetic compounds.

Supplementary key words man • adipose tissue • positional isomers • hexadecenoic and octadecenoic acids • oxidative cleavage • branched fatty acids

Submitted on December 30, 1966
Accepted on March 15, 1967

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