Journal of Lipid Research, Vol. 8, 577-580, November 1967
Copyright © 1967 by Lipid Research, Inc.

Effects of prostaglandin E₁ on lipolysis and plasma free fatty acids in the fasted rat

Floyd P. Kupiecki

Metabolic Diseases Research, The Upjohn Company, Kalamazoo, Michigan 49001

Contrary to published reports, prostaglandin E₁ (PGE₁) in vitro and in vivo inhibited fasting lipolysis in rats. Adipose tissue lipolysis was inhibited when the tissue was incubated in the presence of PGE₁ and when the compound was administered intravenously. A biphasic plasma free fatty acid (FFA) response was obtained in fasted rats after intravenous injection of 80 µg of PGE₁ per kg body weight; plasma FFA concentrations were lowered at 7 min, elevated at 15 min, and at normal concentrations at 30 min. The FFA depression at 7 min was independent of the animal's nutritional state, but the rebound at 15 min did not occur in fed rats. The plasma FFA rebound in fasted rats at 15 min may be a consequence of rapid inactivation of PGE₁, followed by unopposed activity of factors which enhance fasting lipolysis.

Supplementary key words prostaglandin E₁ • rat • lipolysis • plasma free fatty acids • adipose tissue

Submitted on April 12, 1967
Accepted on July 18, 1967

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