Journal of Lipid Research, Vol. 8, 676-681, November 1967
Copyright © 1967 by Lipid Research, Inc.

Composition of phospholipids and of phospholipid fatty acids of human plasma

Gerald B. Phillips and James T. Dodge

Department of Medicine, College of Physicians and Surgeons, Columbia University, New York 10032, and The Roosevelt Hospital, New York 10019

The composition of the phospholipids and of the total phospholipid fatty acids was determined in the plasma of 10 normal subjects. In addition the fatty acid composition of the plasma phosphatidyl ethanolamine, phosphatidyl serine, lecithin, sphingomyelin, and lysolecithin of 6 of the subjects was measured.

A wide array of fatty acids was found in the plasma total phospholipid similar to that found previously in red cell total phospholipid. The fatty acid composition in the plasma phospholipids of a given subject reflected that in his red cell phospholipids.

Each individual phospholipid displayed a distinctive fatty acid pattern, which was generally similar to that of the corresponding phospholipid of red cells, although some marked differences in individual fatty acid levels between the corresponding phospholipids of plasma and red cells were evident.

The high percentage of unsaturated fatty acids found in plasma lysolecithin suggests that this phospholipid did not arise entirely through the enzymatic cleavage of the ßbeta;-fatty acid of lecithin.

Supplementary key words phospholipids • fatty acids • human plasma • phosphatidyl ethanolamine • phosphatidyl serine • lecithin • sphingomyelin • lysolecithin

Submitted on May 1, 1967
Accepted on August 14, 1967

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