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Journal of Lipid Research, Vol. 9, 12-18, January 1968
Copyright © 1968 by Lipid Research, Inc.

Control of lecithin biosynthesis in erythrocyte membranes

Keizo Waku and W. E. M. Lands

Department of Biological Chemistry, The University of Michigan, Ann Arbor, Michigan 48104

The detailed relationship between the relative composition of the potential precursor acids, the esterification rates of their CoA thiol ester derivatives, and the relative composition of the fatty acids in the product, lecithin, which was isolated from normal erythrocytes, suggests that in humans the stromal acyltransferases could be the significant enzymatic factor controlling the fatty acid composition at the 2-position of lecithin in erythrocytes.

Supplementary key words erythrocyte • acyl-CoA:monoacylglycerophosphoryl choline acyltransferase • lecithin • lysolecithin • fatty acid composition • plasma free fatty acids • fatty acyl CoA • membrane

Submitted on July 19, 1967
Accepted on September 27, 1967


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