Journal of Lipid Research, Vol. 9, 85-92, January 1968
Copyright © 1968 by Lipid Research, Inc.

Transfer of locally synthesized cholesterol from intestinal wall to intestinal lymph

Jean D. Wilson and Robert T. Reinke

Department of Internal Medicine, The University of Texas Southwestern Medical School at Dallas, Dallas, Texas 75235

The cholesterol-fed rat subjected to cannulation of the intestinal lymph duct and injected with acetate-2-¹⁴C has been utilized for a study of the mechanism by which cholesterol synthesized in the intestinal wall gains access to the circulation. It has been concluded that locally synthesized cholesterol is excreted bidirectionally, approximately half going into the lymph and half into the lumen. Furthermore, under the condi ions of these experiments, little of the luminal cholesterol appears to be reabsorbed, which suggests that direct transfer from wall to lymph is the principal route for the entry of this endogenously derived cholesterol pool into the lymph and ultimately into the blood stream. Finally, it has been demonstrated that bile is required for this transfer of cholesterol from wall to lymph as well as for the absorption of dietary cholesterol.

Supplementary key words cholesterol • lymph • intestinal wall • lymph duct cannulation • rat • bile • bile duct cannulation

Submitted on July 7, 1967
Accepted on October 6, 1967

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