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Journal of Lipid Research, Vol. 9, 98-102, January 1968
Copyright © 1968 by Lipid Research, Inc.

Hypocholesterolemic activity of 17-methyl-5-androstane-3ßbeta;,17ßbeta;-diol, a metabolite of 17-methyltestosterone

Liese L. Abell and Erwin H. Mosbach

Columbia University Research Service, Goldwater Memorial Hospital, and the Department of Biochemistry and Medicine, Columbia University College of Physicians and Surgeons; and the Public Health Research Institute of the City of New York, Inc., and the Bureau of Laboratories, New York City Department of Health, New York 10009

The hypocholesterolemic activities of 17-methyltestosterone and its major identified fecal metabolite, 17-methyl-5-androstane-3ßbeta;,17ßbeta;-diol, were compared in dogs. The dose-response curves indicated that the two compounds had similar effects, although at doses below 1 mg/kg per day the diol appeared to be more active than the parent compound.

Supplementary key words 17-methyltestosterone • 17-methyl-5-androstane-3ßbeta;,17ßbeta;-diol • hypocholesterolemic agent • dog • serum cholesterol • serum lipoprotein

Submitted on July 31, 1967
Accepted on October 6, 1967

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