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Journal of Lipid Research, Vol. 9, 267-269, March 1968
Copyright © 1968 by Lipid Research, Inc.

Relative contributions of -, ßbeta;-, and -oxidative pathways to in vitro fatty acid oxidation in rat liver

Gabor J. Antony and Bernard R. Landau

Departments of Medicine and Biochemistry, Western Reserve University, Cleveland, Ohio 44106

A method is presented for estimating the relative contribution of -, ßbeta;-, and -oxidation to the metabolism of fatty acids. The distribution of ¹⁴C among the carbon atoms of liver glycogen-glucose is determined after liver slices have been incubated with fatty acids labeled at single points in the chain. When these results are compared with similar data obtained after an incubation with acetate-1-¹⁴C and acetate-2-¹⁴C, conclusions can be drawn about the contributions of -, ßbeta;-, and -oxidation in palmitate, oleate, and stearate, and of oxidative cleavage of the double bond in oleate. ßbeta;-Oxidation is over-whelmingly predominant under the conditions used.

Supplementary key words fatty acid oxidation • -, ßbeta;-, -pathways • unsaturated • oxidative cleavage • liver • rat • in vitro • palmitate-1-¹⁴C • palmitate-16-¹⁴C • stearate-18-¹⁴C • oleate-10-¹⁴C

Submitted on September 5, 1967
Accepted on December 11, 1967

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