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Journal of Lipid Research, Vol. 9, 297-309, May 1968
Copyright © 1968 by Lipid Research, Inc.
Gastrointestinal-Liver Unit, Department of Internal Medicine, The University of Texas Southwestern Medical School at Dallas, Dallas, Texas 75235
In this review experimental data are summarized which indicate that at least four different transport mechanisms account for net movement of bile acids across the gastrointestinal tract. These are active transport and the passive mechanisms of ionic, nonionic, and micellar diffusion.
Of these four, active transport and passive nonionic diffusion are quantitatively of the greatest importance. Active transport is confined to the ileum and probably plays a dominant role in the absorption of conjugated bile acids. Passive nonionic diffusion may occur at any level of the gastrointestinal tract and probably is the major mechanism for the absorption of unconjugated bile acids.
Supplementary key words bile acids • conjugated bile acids • small bowel • large bowel • bile acid transport • passive • active • facilitated diffusion • exchange diffusion • micelles
Submitted on October 23, 1967
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